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  "Description": "Calculates insulin secretion rates from C-peptide values\nbased on the methods described in Van Cauter et al. (1992)\n<doi:10.2337/diab.41.3.368>. Includes functions to calculate\nestimated insulin secretion rates using linear or cubic spline\ninterpolation of c-peptide values (see Eaton et al., 1980\n<doi:10.1210/jcem-51-3-520> and Polonsky et al., 1986\n<doi:10.1172/JCI112308>) and to calculate estimates of input\ncoefficients (volume of distribution, short half life, long\nhalf life, and fraction attributed to short half life) as\ndescribed by Van Cauter. Although the generated coefficients\nare specific to insulin secretion, the two-compartment\nsecretion model used here is useful for certain applications\nbeyond insulin.",
  "License": "GPL (>= 3)",
  "Encoding": "UTF-8",
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  "Repository": "https://kstier.r-universe.dev",
  "Date/Publication": "2026-01-26 18:07:55 UTC",
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